DelveInsight’s, “Vascular Malformations Pipeline Insight, 2025” report provides comprehensive insights about 8+ companies and 8+ pipeline drugs in Vascular Malformations pipeline landscape. It covers the Vascular Malformations pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Vascular Malformations pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Vascular Malformations Pipeline Report

• In June 2025, Xuanwu Hospital, Beijing announced a study is a single-arm exploratory trial conducted by Xuanwu Hospital, Capital Medical University, aiming to evaluate the efficacy and safety of everolimus monotherapy in adult patients with vascular malformations.
• In June 2025, University of Arkansas announced study and potential risks, all patients giving informed consent will go undergo a screening period to determine eligibility for study entry. Patients who meet the eligibility requirements will be given cobimetinib to take by mouth once daily at the same time each day for 21 days and then have 7 days with no treatment. Patients will receive cobimetinib as a tablet (adult) or as a liquid (child).
• In June 2025, Relay Therapeutics Inc. organized a Phase 2 randomized study evaluating the safety and efficacy of the mutant-selective PI3Kα inhibitor, RLY-2608, in adults and children with PIK3CA Related Overgrowth Spectrum (PROS) and malformations driven by PIK3CA mutation. Part 1 is a dose selection, Part 2 is a basket design with exploratory single-arm cohorts for various subpopulations of participants, and Part 3 is randomized, double-blinded study vs placebo.
• DelveInsight’s Vascular Malformations Pipeline report depicts a robust space with 8+ active players working to develop 8+ pipeline therapies for Vascular Malformations treatment.
• The leading Vascular Malformations Companies such as Nobelpharma, Venthera, ONY Biotech, Vaderis Therapeutics, BridgeBio Pharma, Genentech Inc. and others.
• Promising Vascular Malformations Pipeline Therapies such as Everolimus, Alpelisib, Cobimetinib, CYH33, RLY-2608, PTX-022, TARA-002, Ticagrelor, Alpelisib (BYL719), SRM003, and others.

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Vascular Malformations Emerging Drugs Profile

• VT 30: Venthera

VT 30, is a novel investigational therapy is designed to target the genetic drivers of venous (VM), lymphatic (LM), and venolymphatic malformations (VLM) at their source by delivering a potent PI3Kα inhibitor directly to affected tissue. The majority of these cutaneous vascular malformations are driven by somatic mutations in the PIK3CA and TEK genes. These mutations result in overactivation of the PI3K pathway and have been identified as the root cause of the vast majority of VMs, LMs, and VLMs. Because BBP-681 is applied directly to skin lesions, it may minimize complications seen with systemic treatments.

• NPC-12: Nobelpharma

NPC-12, is an investigational drug being developed by Nobelpharma.It is acts as a T lymphocyte inhibitor. Currently, the drug is being evaluated at Phase III for the treatment of vascular anomalies.

The Vascular Malformations Pipeline Report Provides Insights into-

• The report provides detailed insights about companies that are developing therapies for the treatment of Vascular Malformations with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Vascular Malformations Treatment.
• Vascular Malformations Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Vascular Malformations Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Vascular Malformations market

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Vascular Malformations Companies

Nobelpharma, Venthera, ONY Biotech, Vaderis Therapeutics, BridgeBio Pharma, Genentech Inc. and others.

Vascular Malformations pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Ophthalmic
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Vascular Malformations Products have been categorized under various Molecule types such as

• Oligonucleotide
• Peptide
• Small molecule

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Scope of the Vascular Malformations Pipeline Report

• Coverage- Global
• Vascular Malformations Companies- Nobelpharma, Venthera, ONY Biotech, Vaderis Therapeutics, BridgeBio Pharma, Genentech Inc. and others.
• Vascular Malformations Pipeline Therapies- Everolimus, Alpelisib, Cobimetinib, CYH33, RLY-2608, PTX-022, TARA-002, Ticagrelor, Alpelisib (BYL719), SRM003, and others.
• Vascular Malformations Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Vascular Malformations Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Contents

1. Introduction
2. Executive Summary
3. Vascular Malformations: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Vascular Malformations– DelveInsight’s Analytical Perspective
7. Late Stage Products (Phase III)
8. NPC-12: Nobelpharma
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase I/II)
11. VT 30: Venthera
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. Drug name : Company name
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name : Company name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Vascular Malformations Key Companies
21. Vascular Malformations Key Products
22. Vascular Malformations- Unmet Needs
23. Vascular Malformations- Market Drivers and Barriers
24. Vascular Malformations- Future Perspectives and Conclusion
25. Vascular Malformations Analyst Views
26. Vascular Malformations Key Companies
27. Appendix

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